Among veterans receiving opioids, concurrent benzodiazepine use was associated with an overdose-death risk nearly four times as high as opioid use without benzodiazepines.
Sources
- Prevention of Opioid Overdose | New England Journal of Medicine (nejm.org)
- https://www.researchgate.net/publication/278042744_Benzodiazepine_prescribing_patterns_and_deaths_from_drug_overdose_among_US_veterans_receiving_opioid_analgesics_Case-cohort_study (researchgate.net)
- https://pubmed.ncbi.nlm.nih.gov/26063215/?tool=bestpractice.com (pubmed.ncbi.nlm.nih.gov)