Both cluster headaches and migraine have been associated with circadian genes and altered levels of circadian-related hormones, including cortisol and melatonin.
Notes on verification
Confirmed by peer-reviewed Neurology systematic review/meta-analysis (2023), independently corroborated by AAN press release and additional PubMed studies on melatonin/cortisol and circadian genes in headache disorders.
Sources
- Migraine and Cluster Headaches are Linked to the Body's Internal ... (healthline.com)
- https://www.neurology.org/doi/10.1212/WNL.0000000000207240 (neurology.org)
- https://pubmed.ncbi.nlm.nih.gov/36990725/ (pubmed.ncbi.nlm.nih.gov)
- https://www.aan.com/PressRoom/Home/PressRelease/5067 (aan.com)