Caffeine in cocoa may block the effects of dipyridamole (Persantine) or adenosine (Adenocard) used in cardiac stress tests.
Notes on verification
Well-corroborated by peer-reviewed cardiology/nuclear medicine literature and clinical drug interaction databases; mechanism (adenosine receptor antagonism by caffeine) is well-established pharmacology, though clinical significance varies between dipyridamole (more affected) and adenosine (less consistently affected).
Sources
- Cocoa - Uses, Side Effects, and More - WebMD (webmd.com)
- https://www.rxlist.com/supplements/cocoa.htm (rxlist.com)
- https://www.drugs.com/interactions-check.php?drug_list=105-0,914-0&professional=1 (drugs.com)
- https://www.ncbi.nlm.nih.gov/books/NBK555963/ (ncbi.nlm.nih.gov)
- https://www.drugs.com/food-interactions/dipyridamole,persantine.html (drugs.com)
- https://www.sciencedirect.com/science/article/abs/pii/S1071358104001412 (sciencedirect.com)
- https://www.urmc.rochester.edu/conditions-and-treatments/nuclear-cardiology (urmc.rochester.edu)