Studies that trace cell lineage show that brain microglia are replaced by circulating immune cells during ageing.
Sources
- Anatomy articles within Nature (nature.com)
- https://www.nih.gov/news-events/nih-research-matters/immune-cells-cross-blood-brain-barrier-during-human-aging (nih.gov)
- https://www.alzforum.org/news/research-news/brain-ages-infiltrating-monocytes-replace-native-microglia (alzforum.org)
- https://www.science.org/doi/10.1126/science.adt8307 (science.org)
- https://www.the-scientist.com/blood-cells-replenish-microglia-in-the-brain-as-people-age-74859 (the-scientist.com)
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